Journal of Multiple Sclerosis

A lack of sleep is a contributor to cellular stress and damage in neurological disorders.

Emma Reynolds*

A very wide range of illnesses are included in neurological disorders, including those that appear early in development, proceed slowly, or become apparent as people age. The activation of shared pathways, such as the Integrated Stress Response (ISR), and the emergence of shared phenotypes (sleep deficits), despite the fact that the underlying causes of these disorders are distinct, may provide information about some of the mechanistic underpinnings of neurologic dysfunction. The connection between sleep and ongoing stress in the brain, despite being unquestionably complex, has vast implications for understanding neurological illnesses from development to degeneration. Through the disruption of a crucial cellular homeostasis route, the convergent nature of the ISR may serve as a link between genetically different neurological illnesses.