Shweta Pal, Sachin Kumar*, Deepika Aggarwal, Rimpy Dahiya and Vikrant Singh
The most favored method of administering medicine is orally because it is the safest, most convenient, and most cost-effective way. But sometimes conventional oral dosage form can create swallowing related issues in some geriatric and pediatric patients and these issues has been solved by Oral Disintegrating Tablets (ODTs). They are solid unit dosage forms that get dissolves smoothly within the mouth and swallowed without the necessity of hydrating media. It is examining that superdisinterants considered as leading excipients in ODTs. There are several types of super-disintegrants available, including natural and synthetic super-disintegrants. Natural superdisintegrants superior over synthetic ones as they have peculiar and valuable properties like innocuous, biodegradable, chemically inert, economical, ecofriendly,and furnish nutritional supplement. Oral disintegrating tablets have attained popularity in the pharmaceutical company for certain medications with delayed disintegration and limited oral bioavailability. The current study goal highlights and ameliorate the oral disintegrating tablet benefits by the help of natural super-disintegrants like Plantagoovata, Cassia fistula, Hibiscus rosasinesis, Locust bean gum, Chitosan, Aleovera, Fenugreek, Gum karaya, Agar, Guar gum, Soy polysaccharides, Gellan gum, Lepidiumsativummucilage, Aeglemarmelos gum, Dehydrated Banana powder, Ocimumbasilium and Cassia tora. This review relates crucial research studies carried out in the preparation phase of oral disintegrating tablets based on “rapid dissolving” way of deliveryby engaging diverse natural super-disintegrants. Initial investigation focus is to approach quick disintegration along with superior bioavailability by means of patient compliance. Furthermore, the review also highlights and provides a viewpoint regarding future prospectus.
