Sivanandy Palanisamy, Kottur SG Arul Kumaran, Aiyalu Rajasekaran
Objective: The main objectives of the study were to assess the incidence and pattern of ADRs, identifying co-morbidities, past, present illness, assess causality, and offending drugs, monitoring, documenting suspected adverse drug reaction(s) and estimate the cost involved.
Methods: A prospective, spontaneous, reporting study was conducted over a period of 6 months by clinical pharmacists using various scales, namely WHO probability scale, Naranjo’s scale and severity assessed by using modified Hartwig and Siegel scale. The management of reported ADRs and the outcome of the management of ADRs were determined.
Results: A total of 60 ADRs were identified out of which 34 (56.67%) were male and 26 (43.33%) were female patients. The assessment by Naranjo’s scale showed that out of 60 ADR’s 44 (73.33%) ADR’s were possible, 16 (26.67%) were classified as probable and 0 (0.0%) were definitely related to the drug. WHO probability assessment scale revealed that out of 60 ADR’s 43(71.67%) ADR’s were possibly drug-related, 16 (26.67%) ADR’s were probably drug-related and 1 (1.66%) ADR were identified as certain. Severity Assessment by Modified Hartwig and Siegel Scale showed that 35(58.33%) ADRs were moderate, 21(35%) ADRs were mild and 4(6.66%) ADRs were severe. No lethal effects were observed or produced.
Conclusion: Adverse drug reactions (ADRs) related hospital admissions are a significant problem in the health care system. There is a need for a greater awareness among the healthcare professionals, regarding not only the potential for adverse drug reactions but also in the prevention (or) minimization of the occurrence of ADRs.
