Throughout many regions of the world, skin cancer is the most common type of cancer in fair-skinned people. Skin cancer incidence, morbidity, and mortality rates are on the rise, posing a substantial public health problem. The main causative agent in the development of skin malignancies is ultraviolet radiation (UVR). UVR damages DNA and creates genetic mutations, which leads to skin cancer. In order to prevent skin cancer, it is critical to have a deeper understanding of UVR. UVR, its harmful effects on the skin, and its link to UV immunosuppression and skin cancer are discussed in this article. Ozone depletion, UV light elevation, latitude, altitude, and weather conditions all influence the quantity of UVR reaching the earth's surface.