Lung cancer is the main cause of death and morbidity from malignant neoplasms globally, and patients bear a significant burden as a result of its poor prognosis. Smoking is linked to a high percentage of lung cancer cases. A considerable number of nonsmokers develop the disease, implying an epigenetic and genetic pathway for lung cancer development. The current state of lung cancer diagnosis and treatment is dire, and effective therapeutic targets and molecular markers are desperately needed. Circular RNAs (circRNAs) are non-coding RNAs that are covalently closed and have received a lot of attention because of their biological properties like conservatism, stability, and tissue specificity. Many studies have revealed that circRNAs have a key role in the early detection, therapy, and prognosis of lung cancer by regulating it through numerous mechanisms such as microRNA adsorption. CircRNAs have been shown to play a role in the proliferation, migration, and invasion of lung cancer cells in recent years. Differentially expressed circRNAs can be exploited as non-invasive lung cancer diagnostic and prognostic indicators. This article summarizes current circRNA advances in lung cancer diagnosis, treatment, and prognosis.
