Journal of Multiple Sclerosis

Clinically Isolated Syndrome (CIS) Presenting with Ataxia and Ophthalmoplegia

Jayitri Mazumdar, Sumana Kanjilal and Kartik Chandra Ghosh

A clinically isolated syndrome is the result of a single episode of demyelination in one area of the central nervous system (a monofocal episode) or several areas of the central nervous system (a multifocal episode) which lasts for at least 24 hours. Of those who are eventually diagnosed with MS, 85% experience an initial onset of symptoms or a first attack that is referred to as a clinically isolated syndrome (CIS). Here we describe a 10-yr-old-boy with ataxia and ophthalmoplegia, whose MRI showed demyelination only in bilateral fronto- parietal subcortical areas. Patient improved on pulse methyl-prednisolone therapy with tapering dose of steroids and never had recurrence on further follow up till date.