Shammy Jindal, Amit Sharma, Kamya Jindal
Objective: The objective of this study was to develop a floating matrix tablet of Metoclopramide based on HPMC matrices and check the effect of controlled release property of the drug with marketed formulation.
Method: Tablets are prepared by wet granulation method by using HPMC, Sodium starch glycolate and sodium bicarbonate as polymers and excipients. PVP K 30 (5% in IPA) used as granulating agent.
Results: Floating properties of the tablets were determined by determination of density, floating lag time, floating duration and in vitro drug release. Tablets of all the batches had desired buoyancy characteristics.
Conclusion: It was concluded that upon increase in concentration of sodium bicarbonate and sodium starch glycolate in the HPMC matrices sustained the drug release. From the comparison studies it was found that developed formulation were more effective due to patient compliance.
