Md. Shamim Akhter, Md. Amir Hossain, Emran Hossain
Controlled release tablet of Naproxen Sodium in different formulations were included in this study. The effect of the concentration of various polymer products, fillers, and others dissolution criteria on naproxen release rate was studied. Different polymer based matrix tablets were prepared by double compression tablet machine with wet or direct compression. In vitro dissolution tests were performed at different intervals by USP Paddle method II. The dissolution results showed that an increased polymer concentration resulted in reduced drug release. Naproxen dissolved at specified time periods was plotted as percent release versus time (hours) curve. The drug release study was mainly performed for 8 hours because the total gastrointestinal transit time of nutrients and dosage forms in humans approximately 8 hours. We design the controlled release of Naproxen Sodium tablets satisfied with the 1st hour, 4th hour, 8th hour and 20th hour dissolution profile, respectively. To analyze the mechanism of drug release from the matrix tablet, the release data were analyzed by various equations. The data generated in this experiment indicate that various polymers have a great effect on the release rate of naproxen sodium tablet. The higher polymer level and fillers are responsible for the release rate of naproxen sodium. Excipients have negligible effect on the naproxen release.
