Palanisamy.P, R.Margret Chandra, B.Jaykar, B.S.Venkateshwarlu, A.Pasupathi
The main objective of this study was to focus on the hepatoprotective activity Chromolaena odorata King &H. Robinson, with special reference to its curative and protective role in carbon tetra chloride and rifampicin-induced hepatoprotctive animal model.
To fulfill above object in research envisaged the work was to be complete in following manner. To ccollection and authentication of whole plant of Chromolaena odorata king & H.Rob. The dried plant in a soxhlet apparatus by using different solvents in their increasing order of polarity. The extracts were carried out preliminary phytochemical studies, Acute oral toxicity studies and Hepatoprotective activity [Carbon tetra chloride (ccl4 ) induced hepatotoxicity in rats model and its Histopathological studies & Rifampicin induced hepatotoxicity in rats and its Histopathological studies. The phytochemical constuients were identified by chemical tests and these tests showed the presence of various phytochemical constituents like carbohydrate, glycoside, fixed oils, phenolic compounds, alkaloids, flavonoids and tannins. The alcoholic and aqueous extract of whole plant of Chromolaena odorata King & H. Robinson showed the presence of maximum chemical constituents. In the pharmacological studies alcoholic and aqueous extract of whole plant Chromolaena odorata King & H.Robinson showed significant heapatoprotective activity. In last present studies revels that both the alcoholic and aqueous of whole plant of Chromolaena odorata King & H. Robinson can be used as effective hepatoprotective activity. Further experiments are required to prove the mechanism and advantage of alcoholic and aqueous extract whole plant of Chromolaena odorata King & H. Robinson over other drug.
