Shadi Baniasadi, Farzad Kobarfard, Fanak Fahimi
Objective: To set up extemporaneous compounding and determine stability and quality of omeprazole suspension which is not commercially available in Iran.
Methods: We established a compounding service for preparation of oral liquid dosage forms at our center which is a tertiary care hospital. Omeprazole 2 mg/mL were prepared using sodium bicarbonate base, placed in 120 mL glass bottles and stored at 5°C for 28 days. Samples were collected on days 1, 7, 14, 21, and 28 after preparation for analysis by high performance liquid chromatography (HPLC) and assessment of appearance, odor, and pH.
Results: Omeprazole was stable for up to 28 days in the liquid formulations. No substantial changes in the appearance, odor, or pH of any liquid were observed.
Conclusions: Our extemporaneous unit is the first compounding service in Iran where oral liquids such as omeprazole suspension could be prepared according to standard protocols. We plan to extend extemporaneous knowledge in our country in order to prepare commercially unavailable dosage forms for patients.
