R.Margret Chandira, B.Jaykar
The aim of present investigation was to formulate and evaluate the polyherbal tablets containing the aqueous extracts of bark of Albizia odoratissima (L.F) Benth, Leaves of Eryngium foetidum Linn and tuberous roots of Ipomoea digitata Linn for its antidiabetic activity. The present investigation for its phytochemical and pharmacological evaluation. Phytochemical constituents were extracted by successive solvent extraction and identified by chemical test. Aqueous extracts showed the presence of majority of phytoconstituents. Hence it was selected for pharmacological evaluation. The prepared tablets including polyherbal tablets were subjected to hardness, thickness, weight variation, friability and disintegration time and the results showed that the tablets were within the limits of pharmacopeial specifications. All the tablets having good disintegration time between 3 minutes to 4 minutes. Acute toxicity studies were done by OECD guide line 423, LD50, ED50 values were found out. The hyperglycemic activity of plant extracts of Leaves of Eryngium foetidum Linn was significant when compare to the other two plant extract tablets such as bark of Albizia odoratissima (L.F) Benth and tuberous roots of Ipomoea digitata Linn. The formulated tablets containing Gelatin (E6L and E5H) showed significant hyperglycemic effect when compare to the formulations containing HPMC K4M and CMC as polymers. Hence it concluded that the plant leaves of Eryngium foetidum Linn having significant antihyperglycemic activity. The polyherbal formulations were proved effective antihyperglycemic effect than the single drug treatment.
