Glioblastoma (GBM) is a fatal type of brain cancer or primary glial neoplasm, mostly targeting aged populations. The average survival is only 15 mouths from the date of occurrence. It is often observed, the invasive nature of tumour is the main reason for poor prognosis and strong recurrence of GBM in patients even after prescribed treatments. Despite all type of therapy, it is necessary to understand the various molecular mechanisms and signalling pathways to identify targets for GBM treatment. This compilation is specifically design to discuss about Wnt signalling and Hedgehog-GLI1 pathways which have positive and negative regulation against GBM. The recent research finding associated with different signalling pathways for GBM was also been discussed within this article.
