Mayank Bhushan
The occurrence of contiguous diseases poses a great concern regarding public health worldwide particularly with the emergence of resistant bacterial strains against traditionally used organic moieties based antibiotics. Inorganic nanoparticles have the potential of being used as bactericidal agent due to their effective antimicrobial activity, colloidal aqueous stability and comparatively low toxic profile. Owing to their multiple mechanisms of bactericidal activity, inorganic metal oxides and their nanocomposites may serve as a new class of effective disinfectants. This work presents the extensive study on antibacterial properties of novel nanocomposites of α-Fe2O3 with CuO & NiO against pathogenic bacterial strains of B. subtilis, S. aureus, E. coli and S. typhi by using two distinct methods. The prepared nanocomposites were very adequate to combat the bacterial growth and their bactericidal efficiency was comparable to the commercial antibiotic gentamycin. The nanocomposites were synthesized via wet-chemical approach by keeping the iron concentration constant and varying the concentration of other cations in the sample. The samples were further characterized using XRD, TEM, EDAX, Raman, VSM and TGADTA to investigate structural, optical, magnetic and thermal properties of the prepared nanocomposites respectively. Also, the prepared nanocomposites were highly biocompatible and found non-toxic to human cell line MCF7. Thus these non-toxic nanocomposites can be used as the potential antibiotic to counter the diseases caused by normal and multi drug resistant pathogenic bacterial strains.