Zuhair Ali Rizvi
Nausea and Vomiting are one of the most common complications
after major surgeries that may cause dehydration,
water and electrolytes imbalance, aspiration pneumonia,
wound deheiscence and prolonged hospital stay.
This double blind, randomized controlled trial was conducted
on patients undergoing laparoscopic cholecystectomy
in Holy Family Hospital, Rawalpindi after ethical
approval from Rawalpindi Medical University. A total of
100 patients, American Society of Anaesthesiology (ASA)
grade I or II, non smokers, undergoing laparoscopic cholecystectomy
were included in this study using simple
randomized sampling technique. However, patients who
were diabetic, hypertensive, pregnant, unable to understand
visual analogue scale, discharged before 24 hours of
post operative monitoring and those who refused to participate
in the study were excluded. Equal numbers of patients
(50 each) were included in both study groups: those
receiving Ringer’s Lactate (Group R) or those receiving
5% Dextrose Solution (Group D) pre operatively. The primary
outcome of this study was measured by comparing
between both groups the post-operative nausea score at
30 minutes, 60 minutes, 6 hours, 12 hours and 24 hours
which was measured using Verbal Analogue Scale. Data
was entered and analysed using Statistical Package for the
Social Sciences (SPSS v22). There were 29 male and 71
female patients. Mean age was 42.52±14.49 whole Mean
Duration of surgery was 43.06±18.52. Major findings of
this study were that post-operative nausea score was significantly
lower in patients that were pre operatively given
5% dextrose as compared to the patients being given
ringer’s lactate and that post operative nausea score was
neither affected by gender nor by presence or absence of
bile leakage during surgery. Pre operatively given intravenous
dextrose significantly reduces post-operative nausea
as compared to control.
