Gupta Shailesh, Kohli Seema and Sumeet Dwivedi
Somlata (Sarcostemma acidum) belonging to the family Asclepiadacea is grown in India, Europe and US is an underutilized crop. The herb is highly used by the rural and tribal people in curing various disorders like asthma, swelling, fever and cold, dyspepsia, inflammatory infection and gastric problem etc. It is found in dry rocky places in Bihar, Bengal, Konkan, Deccan, Tamil Nadu, Maharashtra, Madhya Pradesh and Kerala. The present study aimed at the evaluation of anti-inflammatory activity of Sarcostemma acidum. Ethyl acetate extract of Sarcostemma acidum was investigated for In-vitro Anti-inflammatory activity by human red blood cell membrane stabilization method. Four different concentration of extract were used for HRBC membrane stabilization method among which concentration at 1 mg/ml showed 30 % protection, con. 2 mg/ml showed 42.8 % protection, con. 4 mg/ml showed 54.0% protection and con.6 mg/ml showed 67.6% protection of HRBC in hypotonic solution. All result show that ethyl acetate extract showed significant membrane stabilizing action on human red blood cell when compared to standard drug Indomethacin which showed 69.6 % protection of HRBC in hypotonic solution. The activity may be due to the presence of one or more phytochemical constituents present in the extract
