Background: Over the past 60 years, as the semiconductor business has grown rapidly, it has been claimed that the number of occupational ailments has also increased. The link between semiconductor employment and malignancies, particularly leukemia, is still debatable among these occupational disorders. Therefore, the associations between semiconductor work, leukemia risk, and cancer risk are evaluated in this systematic review and meta-analysis. Methods: Studies published up through July 31, 2022, were examined in the main scientific databases, including PubMed. All relevant research evaluated the likelihood of cancer in semiconductor sector employees. Results: Following a literature assessment, nine papers were chosen. In each research, semiconductor workers were employed between 1965 and 2009. The risk of leukemia (Relative Risk (RR), 1.02; 95% Confidence Interval (CI), 0.74-1.41) or cancer (RR, 1.00; 95% CI, 0.93-1.07), respectively, was not substantially correlated with semiconductor work. Conclusion: The risk of leukemia or cancer was not shown to be significantly linked with semiconductor work in this meta-analysis. For interpretation, internal comparisons such as non-fab workers, research quality, employment period, and the healthy worker impact should be taken into account. In addition, prospective cohort research based on the entire semiconductor workforce could be helpful to evaluate the risk of occupational disease as a required element of health assessment.
