St. James*, Simone and Supriya
Organoids are three-dimensional, self-organizing structures that mimic human organs and tissues, developed in vitro from stem cells or tissue samples. They offer advantages over traditional cancer cell lines and animal models by replicating the structure and function of human organs or tissues more accurately. Gastrointestinal organoids, which can be derived from the esophagus, stomach, intestine, liver, bile duct, or pancreas, have proven valuable in various applications. Additionally, organoids can mirror the cellular heterogeneity, morphology, and biochemical properties found in living organisms and can be customized to individual patients (known as Patient-Derived Organoids, PDOs). This article explores the tools and underlying mechanisms that make organoids a valuable asset in clinical research.
