Metabolic Syndrome (MetS) and Neurodegenerative Diseases (NDD), such as Alzheimer's disease, Huntington's disease, Parkinson's disease, and depression, are both impacted by the Brain-Derived Neurotrophic Factor (BDNF). If one element is crucial to the pathogenesis of two diseases, then it is likely that these two diseases share the same underlying cause. This study intended to emphasize the significant roles of BDNF in the pathogenesis of MetS and NDD and to propose two distinct preventative or therapeutic approaches, BDNF gene therapy, and BDFN administration, for managing MetS and NDD. One might list cardiometabolic disorders including atherosclerosis, hypertension, Type 2 Diabetes Mellitus (T2DM), obesity, diabetes, and Metabolic Syndrome (MetS) as some of the most prevalent worldwide pathologies. Based on the justification that obesity is one of the main causes of T2DM and that T2DM is linked to obesity, the term "diabesity" was added to this collection. One of the biggest clinical difficulties and worldwide health problems is the MetS, according to experts. It has etiologies connected to modernism, changing eating patterns, excess calorie intake, sedentary lifestyles, and decreased physical exercise. Patients with this group of metabolic disorders are more prone than healthy individuals to developing conditions like Cardiovascular Diseases (CVDs), coronary heart disease, Myocardial Infarction (MI), microand macrovascular dysfunction, type 2 diabetes, cognitive impairment, Central Nervous System (CNS) dysfunction, and early death.
