Journal of Multiple Sclerosis

Natalizumab Associated PML in a Multiple Sclerosis Patient: Excellent Response to Minimal Intervention

Silvia R. Delgado, Efrat Saraf Lavi, Yesica A. Campos, Melissa Ortega, Kottil Rammohan, William A. Sheremata

We present a case of a woman with natalizumab associated progressive multifocal leukoencephalopathy (PML) who developed an immune reconstitution inflammatory syndrome (IRIS) 9 weeks after natalizumab withdrawal. She responded well to a small dose of steroids intravenously, without plasma exchange, and has returned to her baseline status within one year of her initial symptoms and MRI abnormality.