The most common solid tumour in men and the second most common cause of death from cancer in the United States is prostate cancer. The Prostate Working Group (PWG) Cancer Intervention and Surveillance Modeling Network (CISNET) was established in 2000 to address a wide range of questions regarding successful management of prostate cancer. Since PSA screening began in the late 1980s, the PWG analyzed the rapid rise in prostate cancer diagnosis to predict lead time and over diagnosis associated with the testicles.
