Journal of Multiple Sclerosis

Neurodegeneration: An Overview and Recent Advances in Research

Shalom Ni*

Neurodegeneration refers to the progressive loss of structure or function of neurons in the central nervous system, leading to cognitive decline, motor impairments, and other debilitating symptoms. This mini review provides an overview of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. We discuss the underlying mechanisms implicated in neurodegeneration, such as protein mis-folding, oxidative stress, mitochondrial dysfunction, and neuro-inflammation. Furthermore, recent advances in research, including novel therapeutic approaches and potential biomarkers, are highlighted. Understanding the complex processes involved in neurodegeneration is crucial for the development of effective treatments and preventive strategies.