Vijayakumar Arumugam, Abhay Dharamsi, Geetha Kandasamy
Objective: To study the association between obesity and cardiovascular risk factors among Obstructive sleep apnea syndrome (OSAS).
Methods: A prospective study was conducted in patient with excessive day time sleepiness, heavy snoring, air obstruction, breathlessness, and had never been treated for OSAS and were taking no medications were included in the study and they underwent polysomnography
Results: We have included eighty nine OSAS patients with apnea-hypopnea index (AHI) ≥5 events/hr (72 Men and 17 Women). In the study population male patients were comparatively higher 80.89% than female patients (19.10%). The predominance of the disease in male (n=72) with average age of 46.82 ±10.91, but the severity of the disease was same in both male and female. We have examined cardiovascular risk factors, total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), triglyceride (TG), fasting blood sugar (FBS) and C-reactive protein (CRP) levels of study population. The mean serum level of FBS was 107.75 ± 1.86 mg/dl (Mean ± SE), triglyceride was 186 ± 7.93 mg/dl, LDL-c was 118.17 ± 3.38 mg/dl, HDL-c was 33.38 ± 0.96 mg/dl, CRP was 7.33 ± 0.33 mg/L. The Pearson correlation coefficient of AHI with BMI was found to be 0.423 (P<0.0001) with FBS 0.222 (P=0.036), with LDL-c 0.231 (P=0.028) with TG 0.218 (P=0.039). AHI showed a significant positive correlation with BMI, FBS, CRP, TG, and LDL-c. Elevated levels of CRP were found in 64% (n=57) of population in our study.
Conclusion: Our study confirms the other reports to increasing BMI, the prevalence of elevated CRP levels. Our results show that OSAS is associated not only with BMI but also with increased CRP concentrations and elevated Triglycerides and LDL-c, FBS
