Osteoporosis is a condition with a mostly unidentified pathomechanism that is frequently referred to be a "silent thief" because it typically only manifests when fractures happen. This suggests that the pathological harm takes place before pain is felt. Therefore, in a quad-phasic non-contact injury pathway, ageing may eventually lead to the metabolic imbalance of primary osteoporosis. It is also emphasized that delayed onset muscle pain, non-contact anterior cruciate injury, and osteoporosis may all have the same initiating proprioceptive non-contact Piezo2 channelopathy at different sites, but with different environmental risk factors and a different genetic predisposition, leading to different longitudinal outcomes.
