Mohammad asif
Vrious antitubercular agents are used the control and treatment of tuberculosis (TB). Currently, various works is going on in the research and development of new antiTB drugs for less side effects, more potent, short period of therapy and more importantly acive against multi drug resistant strains of Mycobacterium. In this continuation we study here thiolactomycin (TLM) and it analogues as anti-TB agent and effect of various substituents on TLM for development of more effective molecule with considerable potential. TLM is naturally occurring and exhibited potent in-vivo activity against many pathogenic bacteria including Mycobacterium strains. TLM inhibits bacterial and plant type-II fatty acid synthases (FAS-II) but not effective in mammalian or yeast type-I fatty acid synthases (FAS-I). This review provides an overview on the TLM derivatives and their structure activity relationship.
