Neurological symptoms and indications show the presence of targets other than the major lung consequences of the Coronavirus Disease 2019 (COVID-19) pandemic. The SARS-CoV-2 coronavirus, which is the cause of COVID-19, demonstrates neurotropism for both the central and peripheral nervous systems. The virus can access the central nervous system by a variety of infective mechanisms and pathways, some of which skip the blood-brain barrier and others that compromise its integrity. There can be no doubt that the membrane-bound metalloprotease ACE2 serves as the SARS-CoV-2 host-cell receptor, according to a number of studies. The cellular location of the ACE2 enzyme in many tissues, including the central nervous system, has been examined using histochemical investigations and more recently, transcriptomics of mRNA.
