The stem cell/material interface may be a complex, dynamic microenvironment during which the cell and the material cooperate directly with another cell by remodeling its surroundings, and therefore the material through its inherent properties (such as adhesively, stiffness, nanostructure or degradability). Stem cells in touch with materials are ready to sense their properties, integrate cues via signal propagation and ultimately translate parallel signaling information into alternate cells. However, discovering the mechanisms by which stem cells are highly complex potential to develop into many different inherent cell characters due to the multicomponent signaling to present within the somatic cell environment. During the previous study, we discuss recent evidence that shows inherent material properties could also be engineered to somatic cells, and overview a subset of the operative signal transduction mechanisms that have begun to emerge. Further developments in somatic cell engineering and mechanotransduction are poised to possess substantial implications for biological somatic cell and regenerative medicine.
