Because neurons are not very good at regenerating, trauma and neurodegenerative illnesses of the Central Nervous System (CNS) are challenging to treat. A traditional strategy for neuroregeneration involves engrafting neural stem cells into the CNS. Despite significant advancements, functional integration and overcoming immune-rejection remain obstacles for stem cell therapy. In the adult mammalian CNS, a new development known as neuronal reprogramming transforms endogenous non-neuronal cells (such as glial cells) into mature neurons.
