Background and Aims: The present paper introduces and thematizes cuttingedge topics in bridging humanistic and medical sciences by analyzing different facets of art-making, conceptualized most comprehensively as regards various types of artistic language in their overlapping moments with therapeutic potentialities and ecological awareness. It entails in utmostly impactful way psyche and soma interactions from a neurobiological perspective within a framework of positive psychology with the scope of bringing to light psychoanalytically and cross-culturally concomitant artistic and ecological mindfulness regarding clinical toolkits and practical strategies. Methods: This paper showcases through clear and precise descriptions a wide-ranging set of artistically motivated examples showing the modalities of how they can be applied and integrated into the work of clinicians through the lens of art therapy imbued with ecological mindedness. The attention will be given to affect-regulating cognitive-experiential aspects mediated through psychoanalytic theory and arts-based eco-therapeutic exercises by observing pre-symbolic and sensory information as well as mental representations and imaginative elements stemming therefrom. Findings: The paper underlines how involvement in the practice of creative arts can lead to reparative experiences so as to produce further emotional attunement with investment of unconscious material and symbolic apparatus. Structurally, the content of this paper covers the entire formal artistic kaleidoscope by indicating and commenting a variety of typological distinctions such as imagistic, musical, literary, architectonic expressions together with their verbal reflections, including gathering observations from journaling of inner experiences, placed in constant relation to the natural element with the objective of realization of mental health. Conclusion: This paper, belonging to the interdisciplinary spheres of environmental and medical humanities is aimed at explaining the productive entanglements between these fields with a particular focus on recent developments together with their clinical implications bringing breakthrough cognitions.