Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Abdul Mannan Baig
Stadium Road, Karachi
Pakistan
Review Article
Mitochondrial DNA Mutation in Microglia Can Be Treated by SCNT Cloning and Not by Reprogramming of Olfactory Ensheathing Cells in the Multiple Sclerosis Treatment
Author(s): Abdul Mannan BaigAbdul Mannan Baig
Background: Multiple sclerosis (MS) is a demyelinating chronic inflammatory neurological disease of the central nervous system (CNS), characterized by activation of microglia. Mitochondrial mutations (mtDNA.mutat) and dysfunctions inmicroglial cells are thought to centrally contribute to the damaging effects of neuroinflammation seen in MS.
Objective: The somatic nuclear transfer (SCNT) technology offers a more practical mode of therapy in MS, This method would attempt to dilute and/or progressively replace the (mtDNA.mutat) and activated microglia with cloned olfactory ensheathing cells (OEC) with remyelinating and scavenging properties which would attempt to limit the progression of MS.
Proposed Methods: Applying SCNT-derived embryonic stem (ES) cells based therapy by cloning olfactory ensheathing cells (OEC), en.. View More»
