Abraham Nigussie Mekuria
Department of Health and Medical Sciences,
Harari
Ethiopia
Review Article
Drivers of Glucose and Glutamine Metabolism Reprogramming in Tumor Cells and Their Potential as Target for Cancer
Author(s): Abraham Nigussie Mekuria and Abraham Degaga AbdiAbraham Nigussie Mekuria and Abraham Degaga Abdi
Malignant cells undergo a metabolic transformation to satisfy the demands of growth and proliferation. This metabolic reprogramming has been considered as an emerging hallmark of cancer. It is well established that most normal cells get energy first via glycolysis in the cytosol that is followed by mitochondrial oxidative phosphorylation (OXPHO) under aerobic conditions but when oxygen is scarce, glycolysis rather than OXPHO for energy supply. However, cancer cells prefer to perform glycolysis in the cytosol even in the presence of oxygen, a phenomenon first observed by Otto Warburg and now famously known as ‘’Warburg effect’’ or ‘’aerobic glycolysis’’. Such reprogramming of glucose metabolism has been validated within many tumors, and increased glycolysis facilitates biosynthesis of biomass (e.g., nucleotides, amino acids and lipids) by.. View More»
