Addepalli VA
India
Research Article
A Possible Mechanism of Antidepressant like Effect of Recombinant Human Erythropoietin
Author(s): Pawar AS, Barve KH, Patel A, Raje A and Addepalli VAPawar AS, Barve KH, Patel A, Raje A and Addepalli VA
Objective: Recombinant human erythropoietin is clinically proved to have antidepressant like effect. The present
study deals with evaluating the possible mechanism of action of the antidepressant effect of recombinant human
erythropoietin (rH-Epo).
Methods: The antidepressant activity of subcutaneously administered rH-Epo was tested in models of acute
stress and chronic stress. Simultaneous administration of rH-Epo in sub-effective dose with sub-therapeutic doses of
standard anti-depressants/agonist and antagonist of various receptors was done in mice to study the potential
mechanism of antidepressant effect of rH-Epo using the tail suspension test. One-way or two-way ANOVA, followed
by post- Turkey test and Paired T test were applied wherever appropriate.
Results: In acute stress model, rH-Epo produced significant decrease in im.. View More»
