Adekanle DA
College of Health Sciences,
P.M.B. 4400, Osogbo, Osun State
Nigeria
Research Article
Comparison of Intramuscular Magnesium Sulphate with Low Dose Intravenous Regimen in the Management of Eclampsia in Low Resource Setting: A Randomised Study
Author(s): Idowu A, Adekanle DA, Loto OM, Ajenifuja KO, Badejoko OO, Tijani Am and Mustapha AOIdowu A, Adekanle DA, Loto OM, Ajenifuja KO, Badejoko OO, Tijani Am and Mustapha AO
Background: Eclampsia is a major cause of maternal and perinatal morbidity and mortality. Magnesium sulphate is currently the gold standard in the management of eclamptic fit. As a result of its toxicity, current efforts are being geared towards discovering a lower dosage without compromising its efficacy.
Objective: To compare the effectiveness of low-dose magnesium sulphate and standard Pritchard regimen in controlling eclamptic fit and preventing adverse maternal and neonatal outcomes in eclamptic patients
Methodology: This study was a randomized clinical trial comparing low-dose with standard Pritchard regimen. Twenty eight patients (the cases) randomized into low-dose regimen group received 4g loading dose, I.V. 4 g and a maintenance dose of 0.6 g/hr through intravenous infusion for a period of 24 hours post-d.. View More»
