Research Article
Improved Coronary Sinus Blood Sampling for Cardiac Research
Author(s): Sam Dawkins, Mohammad Alkhalil, Giovanni Luigi De Maria, Gregor Fahrni, George Kassimis, Regent Lee, Niket Patel, Adrian P. Banning, Robin P. Choudhury, Colin Forfar, Rajesh Kharbanda, Jeremy P. Langrish, Andrew J. Lucking and Keith M. ChannonSam Dawkins, Mohammad Alkhalil, Giovanni Luigi De Maria, Gregor Fahrni, George Kassimis, Regent Lee, Niket Patel, Adrian P. Banning, Robin P. Choudhury, Colin Forfar, Rajesh Kharbanda, Jeremy P. Langrish, Andrew J. Lucking and Keith M. Channon
Background: Coronary sinus (CS) blood sampling is important for measuring metabolites and biomarkers in cardiovascular research, but can be technically challenging. Here we demonstrate the use of the antecubital fossa for CS blood sampling as an alternative to femoral access, and a simple technique of paired venous and CS blood gas analysis for confirmation of valid CS sampling. We also demonstrate improvement in sampling accuracy by using a coronary guide wire to stabilize the sampling catheter in the CS.
Methods: Paired blood samples from CS and peripheral vein were collected from patients at the time of primary PCI for acute myocardial infarction. Venous access for CS sampling was via the antecubital vein. Blood gas analysis was used to confirm a true CS sample (pO2[CS] Results: 108 patients underwent CS and peripheral venou.. View More»
