Agussalim A
Health Polytechnic of Jayapura,
Indonesia
Research Article
Polymorphism Genes Sulfonylurea Receptpr-1 and Potassium InwardlyRectifying Channel Subfamily J Member 11 as a Risk Factor for Type 2 Diabetes Mellitus in Ethnic of Ternate
Author(s): Muhammad AA and Agussalim AMuhammad AA and Agussalim A
Background: Sulfonylurea Receptor-1 (SUR1) and Potassium Inwardly-Rectifying Channel Sub Family J Member 11 (KCNJ11) is the gene at canal its activity of ATP sensitive potassium (KATP). Canal KATP ATP acts as a sensor on the settings of the secretion of insulin. Polymorphism R1273R E23K genes SUR1 and KCNJ11 cause interference with the activity of the Canal KATP, affect the secretion of insulin causing hyperglycemia and Impaired Glucose Tolerance (IGT) are at risk of type 2 DM occurs.
Purpose: Examine the interconnectedness of Polymorphism R1273R E23K genes SUR1 and KCNJ11 as risk factors of type 2 DM on Ternate Ethnic.
Methods: The case-control Design to the subject research of sufferers of type 2 DM (n=52) as Group cases and subject to the Non-DM (n=52) as a control group. Genotyping gene is done by the method of.. View More»
