Alfred Chun-Shui LUK
Hong Kong
Review Article
The Interplay of Coding and Non-Coding Regulations in Mouse Spermatogenesis
Author(s): Alfred Chun-Shui LUK and Tin-Lap LEEAlfred Chun-Shui LUK and Tin-Lap LEE
Spermatogenesis is an essential biological process to produce functional male gametes from undifferentiated progenitor cells throughout the reproductive age. Success in a series of differentiation of stem cell-like progenitor cells is a complex cascade and involves sophisticated regulations by various types of molecules in the developing germ cell. In this review, we will discuss the role of different groups of germline biomolecules, including some protein coding genes, microRNAs, piRNAs and long non-coding RNAs (lncRNAs) in leading to a complete cycle of mouse spermatogenesis. We will also share our perspective on future research opportunities on lncRNA regulations in spermatogenesis. Development of male gametes in mammals is regarded as one of the most efficient biological processes, which is characterized by a continuous production of sperms from puberty till the end of reproductiv.. View More»
