Ali Sepehrinezhad
West Indies
Research Article
The Relationship between Liver Dysfunction, Electrocardiographic
Abnormalities and Metabolism in Rat
Author(s): Farzaneh Ketabchi, Ali Sepehrinezhad and Amirreza DehghanianFarzaneh Ketabchi, Ali Sepehrinezhad and Amirreza Dehghanian
Introduction: Liver disorders may lead to many critical complications such as electrical heart abnormalities. The aim of this study was to investigate the relationship between the severity of liver dysfunctions, electrocardiogram variables and oxygen consumption.
Methods: Female Sprague Dawley rats were divided into 4 groups of sham, partial portal vein ligation (PPVL), common bile duct ligation (CBDL), and combination of them (CBDL+ PPVL). 28 days after the first surgery, animals were anesthetized; ECG recorded and right femoral artery and vein cannulated. Blood gas parameters and complete blood count were measured and the arterial-venous oxygen content difference (A-VO2) calculated.
Results: QT interval and QTc in the CBDL+PPVL and CBDL groups were longer than those of the sham and PPVL groups. Furthermore, .. View More»
