Amany Abd El-Fattah El-Shazly
Cairo
Egypt
Research Article
Therapeutic Effects of Extracts from Spirulina platensis versus Bevacizumab on Inflammation-Associated Corneal Neovascularization
Author(s): Amany Abd El-Fattah El-Shazly, Asmaa Ibrahim Ahmed, Yasser Abdelmageuid Elzankalony and Walid Mohamed Abd El Raouf El-ZawahryAmany Abd El-Fattah El-Shazly, Asmaa Ibrahim Ahmed, Yasser Abdelmageuid Elzankalony and Walid Mohamed Abd El Raouf El-Zawahry
Aim: The aim of this work was to study histological and immunohistochemical changes resulting from corneal alkali burn and to assess these changes after treatment with either polysaccharide extract from Spirulina platensis (PSP) or Bevacizumab.
Methods: Alkali burn was induced in corneas by direct application of a filter paper ring (2.5 mm diameter) saturated with 1 N NaOH and applied to the center of the rat corneas for 30 seconds. PSP (extracted from dry powder of Spirulina platensis) and avastin were administered topically on the corneas 4 times daily for 7 days starting 7 days after induction of corneal alkali burn. The therapeutic effects of PSP and avastin were evaluated daily using slit-lamp. At the end of the therapy, corneas were harvested for H and E staining, Masson trichrome staining, immunohistochemical study for .. View More»
