Journal of Multiple Sclerosis
ISSN - 2376-0389NLM - 101654564
Andreas Kastrup
Germany
Research Article
No Effect of Cooling on Cognitive Fatigue, Vigilance and Autonomic Functioning in Multiple Sclerosis
Author(s): Anja Gossmann, Paul Eling, Andreas Kastrup and Helmut HildebrandtAnja Gossmann, Paul Eling, Andreas Kastrup and Helmut Hildebrandt
Background: Fatigue is a common symptom in Multiple Sclerosis (MS) and body cooling may be an important non-pharmacological treatment strategy for fatigue by, for instance, reducing the loss of axonal conduction efficiency due to Uhthoff’s phenomenon. However, up to now, no studies have demonstrated such a treatment effect for mentally induced fatigue.
Methods: In this single-blinded randomized placebo controlled cross-over design we studied the effects of cooling on cognitive fatigue and autonomic functioning (heart rate variability and sympathovagal balance measures) during a vigilance task in 31 MS patients and 10 controls.
Results: Task performance, fatigue and sympathovagal balance did not differ between verum- and placebo condition after controlling for depressive mood. MS patients showed more omissions on .. View More»
DOI: 10.4172/jmso.1000112
