Astra Vitkauskiene
Lithuania
Research Article
Associations of HLA DRB1 Alleles with Igg Oligoclonal Bands and Their
Influence on Multiple Sclerosis Course and Disability Status
Author(s): Renata Balnyte, Daiva Rastenyte, Antanas Vaitkus, Ingrida Uloziene, Astra Vitkauskiene and Erika SkrodenieneRenata Balnyte, Daiva Rastenyte, Antanas Vaitkus, Ingrida Uloziene, Astra Vitkauskiene and Erika Skrodeniene
Background: Oligoclonal bands (OCB) may be associated with the genes of HLA complex, which allows to
consider the possible interaction of genetic and immunological factors and its importance in the development and
progression of multiple sclerosis (MS).
Aim: To evaluate the importance of the associations between HLA DRB1 alleles and oligoclonal bands (OCB) in
the multiple sclerosis (MS) patients disease course and disability.
Metods: This was a prospective study of 120 patients with MS. HLA DRB1 alleles were genotyped using the
polymerase chain reaction. Matched cerebrospinal fluid (CSF) and plasma samples were analysed using isoelectric
focusing and IgG specific immunofixation to test for the presence of intrathecal specific OCB and compared directly
with the serum samples.
Results: HLA DRB1*08 allele be related to lower .. View More»
