Awad Ali
India
Research Article
Repositioning of Solifenacin and Hydroxyzine as Antibiofilm Agents in Candida albicans
Author(s): Sankunny Mohan Karuppayil and Awad AliSankunny Mohan Karuppayil and Awad Ali
Biofilm growth and drug resistance by Candida albicans can cause serious health problems in immunocompromised patients. Therefore there is a necessity for developing novel drugs. One of the strategies is repositioning of drugs. Solifenacin is a muscarinic receptor antagonist used for overactive bladder treatment. While Hydroxyzine is an anti-allergy drug and also it has mild anti-muscarinic receptor effect. In this manuscript, the effect of Solifenacin and hydroxyzine against C. albicans virulence factors is reported. It is found that Solifenacin and Hydroxyzine inhibited biofilm formation, adhesion, growth and morphogenesis in C. albicans. C. albicans Rrp9, an essential protein is found to exhibit identity and similarity with muscarinic receptor M1. A docking study between Hydroxyzine and C. albicans Rrp9 revealed good binding energy. Mole.. View More»
