Can Ozan Tan
Cardiovascular Research Laboratory, Spaulding Hospital Cambridge, 1575 Cambridge Street, Cambridge, MA 02138,
Tanzania
Review Article
Spinal Cord Injury and Osteoporosis: Causes, Mechanisms, and Rehabilitation Strategies
Author(s): Can Ozan Tan, Ricardo A Battaglino and Leslie R MorseCan Ozan Tan, Ricardo A Battaglino and Leslie R Morse
Spinal cord injury (SCI) has a huge impact on the individual, society and the economy. Though advances in acute care resulted in greatly reduced co-morbidities, there has been much less progress preventing long-term sequelae of SCI. Among the long-term consequences of SCI is bone loss (osteoporosis) due to the mechanical unloading of the paralyzed limbs and vascular dysfunction below the level of injury. Though osteoporosis may be partially prevented via pharmacologic interventions during the acute post-injury phase, there are no clinical guidelines to treat osteoporosis during the chronic phase. Thus there is need for scientific advances to improve the rehabilitative approaches to SCI-related osteoporosis. Recent advances in application of a new technology, functional electrical stimulation, provide a new and exciting opportunity to improve bone metabolism and to provide mechanical s.. View More»
