CSG Spilla
Brazil
Review Article
Neuroanatomical Mapping of s100 Immunoreactivity Reviewed
Author(s): LMG Campos, L. Pinato, CSG Spilla, AL Decanini, IZ Vieira, MY Hamasaki and MI NogueiraLMG Campos, L. Pinato, CSG Spilla, AL Decanini, IZ Vieira, MY Hamasaki and MI Nogueira
S100B is a small calcium-binding protein expressed primarily by astrocytes involved in several pathologies. Several studies have shown S100B protein immunoreactivity (S100B-IR) in brain specific areas, and some of them showed the cells identity under physiological and/or pathological conditions. This review reports the S100BIR distribution in the brain specific areas of different adult mammals and complement with our results in order to provide a complete overview about the S100B-IR distribution and cell identity. This review highlights a heterogeneous distribution of S100B-IR in prosencephalic, diencephalic, brainstem and cerebellum areas. Regarding cellular identity, the co-localization of S100B-IR and GFAP-IR occurred predominantly in periventricular areas, in the hippocampus and the septal area in contrast with cortical regions. In addition, cells S100B-IR but not GFAP-IR were als.. View More»
