Dale E. Bredesen
Easton Laboratories for Neurodegenerative Disease Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095,
Tanzania
Research Article
Alzheimer's Model Develops Early ADHD Syndrome
Author(s): Qiang Zhang, Guiping Du, V John, Pankaj Kapahi and Dale E. BredesenQiang Zhang, Guiping Du, V John, Pankaj Kapahi and Dale E. Bredesen
We describe the first invertebrate model of attention deficit hyperactivity disorder (ADHD) that reproduces its major features, including hyperactivity, male predominance, marked exacerbation by simple carbohydrates, reversible response to dextroamphetamine, and a “paradoxical response” to stimulants. This model may offer new insight into ADHD pathogenesis and treatment. Furthermore, these findings are of particular interest in light of the recent epidemiological evidence showing that patients with dementia have a high frequency of antecedent ADHD symptoms.
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