Derrick J Feenstra
Tanzania
Review Article
Modes of Retinal Cell Death in Diabetic Retinopathy
Author(s): Derrick J Feenstra, E. Chepchumba Yego and Susanne MohrDerrick J Feenstra, E. Chepchumba Yego and Susanne Mohr
Cell death seems to be a prominent feature in the progression of diabetic retinopathy. Several retinal cell types have been identified to undergo cell death in a diabetic environment. Most emphasis has been directed towards identifying apoptosis in the diabetic retina. However, new research has established that there are multiple forms of cell death. This review discusses the different modes of cell death and attempts to classify cell death of retinal cells known to die in diabetic retinopathy. Special emphasis is given to apoptosis, necrosis, autophagic cell death, and pyroptosis. It seems that different retinal cell types are dying by diverse types of cell death. Whereas endothelial cells predominantly undergo apoptosis, pericytes might die by apoptosis as well as necrosis. On the other hand, Müller cells are suggested to die by a pyroptotic mechanism. Diabetes leads to signifi.. View More»
