Dorte Phillip
Denmark
Research Article
Spontaneous Low Frequency Oscillations in Acute Ischemic Stroke - A Near Infrared Spectroscopy (NIRS) Study
Author(s): Dorte Phillip, Henrik W Schytz, Helle K Iversen, Juliette Selb, David A Boas and Messoud AshinaDorte Phillip, Henrik W Schytz, Helle K Iversen, Juliette Selb, David A Boas and Messoud Ashina
Background and purpose: Continuous wave near infrared spectroscopy (NIRS) is a non-invasive bed-side optical method to detect changes in oxygenated (oxyHb) and deoxygenated hemoglobin (deoxyHb) in the outermost layers of the cerebral cortex. Cortical oxyHb low frequency oscillations (LFOs) in the 0.09-0.11 Hz range are affected by changes in cerebral autoregulation (CA), which is altered following stroke. We examined oxyHb LFOs at bed-side as a marker of CA in the subacute phase in stroke patients with or without recombinant tissue plasminogen activator thrombolytic therapy. Methods: We recruited 29 patients admitted to the stroke unit with symptoms of ischemic stroke. 11/29 patients received thrombolytic therapy. NIRS examination was conducted 2 days (median time) from stroke onset. NIRS optodes were placed on each side of the head with a 3 cm source-detector distance. Using transfer.. View More»
