Ehrlé Nathalie
Service de Neurologie, CHU de Reims 45, rue Cognacq Jay, 51092 Reims Cedex,
France
Research Article
Short-Term Memory Impairment Sparing the Central Executive in Relapsing-Remitting Multiple Sclerosis?
Author(s): Ehrlé Nathalie, Omigie Diana, Saenz Amaya, Debouverie Marc, Rumbach Lucien, Chaunu Marie-Pierre and Bakchine SergeEhrlé Nathalie, Omigie Diana, Saenz Amaya, Debouverie Marc, Rumbach Lucien, Chaunu Marie-Pierre and Bakchine Serge
Objective: It is widely accepted that working memory (WM) impairment has a high incidence in multiple sclerosis
(MS). However, this WM impairment has rarely been analyzed with reference to a cognitive model. The aim of the
study was to determine whether dysfunction in MS is due to WM or short-term memory deficits.
Methods: We assessed the components of Baddeley's WM cognitive model, which include the phonological loop,
visual sketch and central executive. Seventeen conditions implicating short term memory and executive functions
(flexibility, inhibition, manipulation) were carried out by128MS patients diagnosed with RRMS, and 30 age matched
healthy controls. Also assessed were three tasks of motor speed namely the Overt articulation rate, Digit-symbol
copy test and Digit-symbol coding test.
Results: In all but three conditions, t.. View More»
