Eishin Morita
Japan
Review Article
Wet Earwax Phenotype Determined by ABCC11 Polymorphism is a Highrisk Factor for Acne
Author(s): Yasuyuki Sumikawa, Hitoshi Takahashi, Masuko Sumikawa, Kenji Kusatake, Sakae Kaneko, Toshiharu Yamashita and Eishin MoritaYasuyuki Sumikawa, Hitoshi Takahashi, Masuko Sumikawa, Kenji Kusatake, Sakae Kaneko, Toshiharu Yamashita and Eishin Morita
Background: The type of earwax-wet or dry-is determined by a single nucleotide polymorphism (SNP)-538G>A (Gly180Arg)-in the ABCC gene (ABCC11), which encodes an ATP-binding cassette domain. Since axillary osmidrosis is closely related to earwax type, some dermatoses may be associated with earwax type.
Objectives: We analyzed the association between the prevalence of a series of dermatoses and earwax phenotype. Further, we investigated ABCC11 localization in the skin.
Methods: A total of 660 patients who visited Nopporo Dermatology Clinic in Hokkaido were enrolled in this study. The patients were interviewed to determine their earwax type-wet or dry-and a medical practitioner diagnosed dermatoses. The association between the prevalence of dermatoses and earwax type was analyzed statistically. ABCC11 localization in t.. View More»
