Fairus Ahmad
Malaysia
Research Article
Potential Benefits of Annatto Tocotrienol in Glucocorticoid Induced Osteoporosis: An Animal Study
Author(s): Ima Nirwana Soelaiman, Elvy Suhana Mohd Ramli, Farihah Suhaimi and Fairus AhmadIma Nirwana Soelaiman, Elvy Suhana Mohd Ramli, Farihah Suhaimi and Fairus Ahmad
Long-term glucocorticoid treatment induces oxidative stress that cause osteoporosis is an antioxidant and has protective effects against free radical associated diseases. Annatto tocotrienol is a tocopherol free tocotrienol mixture. The purpose of this study was to determine the effects of annatto tocotrienol against glucocorticoid-induced osteoporosis. 32 adult male Sprague-Dawley rats were used in this study. 16 rats were adrenalectomized and divided into two groups; Adrx+Dexa and Adrx+Dexa+ATT and were administered with intramuscular injection of dexamethasone 120 μg/kg/ day. Eight rats underwent sham procedure and the other 8 serves as baseline group. The Adrx+Dexa group was given vehicle palm olein 0.1 ml/kg/day orally while Adrx+Dexa+ATT group was supplemented with annatto tocotrienol 60 mg/ kg/day. The sham operated rats were given vehicle palm olein 0.05 ml/kg/day by intr.. View More»
