Federico Licastro
Via S. Giacomo 14, 40126 Bologna
Italy
Review Article
Individual Risk Detection of Developing Cognitive Decline and Dementia in Adults with Down’s Syndrome
Author(s): Federico Licastro and Elisa PorcelliniFederico Licastro and Elisa Porcellini
Alzheimer’s disease (AD) is a neurodegenerative brain alteration and a leading cause of cognitive decline and dementia and incidence and prevalence of AD are increasing in both industrial and rural societies. However, in spite of intensive research during last thirty years no effective medication is available. Neuropathological AD hallmarks are amyloid deposition and neurofibrillary tangles, however, presence of these brian deposits do not completely explain the disease’s pathogenesis. Recently Aβ peptide, the proteinaceous precursor of brain amyloid deposits, has been proposed as an anti-microbial factor. Recent investigations have indeed shown that virus and/or bacterial infections influenced the clinical history of AD. Genotypic, phenotypic, epidemiological and clinical variables have been associated with an increased risk of cognitive decline or dementia as assese.. View More»
