Fedorova NB
Novosibirsk, 630090
Russian Federation
Research Article
Genes and Ontogenes in Drosophila: The Role of RNA Forms
Author(s): Fedorova NB, Chadova EV and Chadov BFFedorova NB, Chadova EV and Chadov BF
The independent hereditary factors, such as Mendelian genes, are not sufficient for the existence and operation of genetic systems. The hereditary factors of different type were searched for. A new class of mutations, referred to as conditional mutations, was discovered in Drosophila melanogaster. Such a mutation dies in a restrictive genotype but survives and reproduces in a permissive genotype. Besides their conditional nature, mutations in a permissive genotype display a set of specific features that drastically distinguish them from conventional mutations, namely, they (1) are dominant; (2) are as a rule, lethal; (3) have drastically decreased fertility; (4) interact with chromosomal rearrangements; (5) switch the genome from a stable to an unstable state; (6) increase the basal metabolism; (7) induce modifications and morphoses; and (8) their manifestation is inherited i.. View More»
